This version was ported to the Game Boy by Factor 5, but due to space constraints, only three levels are present in this version and certain parts of the three levels are absent. When they smile, they are healthy, but when they are looking either tired, unhappy, or weak, then they should find health soon (which is found in the forms of several forms of ice cream or sweets, or other kinds of food). Their health is indicated by their faces on the top left of the screen.

The lives can be increased by obtaining either 100 stars or obtaining a small golden form of their faces. The Warner Brothers and Sister have health indicators and a number of lives. Dot is able to blow kisses which, when used on certain characters, triggers certain actions needed to progress. Wakko uses a mallet that can be used to hit switches, break certain objects, and light fuses. Yakko uses a paddleball to stun enemies and is also able to push and pull objects such as crates. Players control Yakko, Wakko, and Dot, switching control between them to use their respective powers accordingly. After clearing all five levels, players travel to the final level where they must fight Pinky and the Brain. A fifth level will then open to obtain a final piece of movie memorabilia. The player must reach the end of each level and beat the boss to obtain a piece of movie memorabilia.

The game features four main levels, which can be entered in any order.

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